no|||A 22-250 probably wont even fit into the action of a .22|||Not even close. Have you seen the difference in cartridges sizes, not to say anything about the one being a rimfire and the other a centerfire.
Rule of thumb: Use only the ammo your firearm was designed to shoot.
H|||Absolutley not.|||Check the Henry website to get the info on this gun. To the best of my knowlege, it only comes chambered for the .22 rimfire cartridges.|||no it is a 22 lr rimfire cartrage.and the 22-250 is a centerfire cartrage|||Nope --- Take a look at the below links|||No, it only shoots 22LR only.|||nope just 22 short, long and long rifle
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